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[ Saturday, April 26, 2008 07:02 ]

Legacy Journal: Saturday Prep

Section:
None

Summary:
* RITMemoire3: Billy_and_the_Bike.pdf

Three point standardization and check list lessons: Communicating was you sense , Analysis of what you sense, & Action plan. Document what you know, not what you feel.

* Big Sur to Carmel Marathon Race.

Main:
: Redmond, Deschutes, Three Sisters, John Charles Fremont, and more.

:: Better your communication and your outcomes by building a World Class High Reliability Organization. Start with Standards

::: For weekend warriors.

More:

Footnotes:

Posted by: webscribe2 on 04/26 at 07:02 AM
Backgrounder: • Basics: • Burden of Proof: • Calendar: • Saturday: • Chronicles: • Courage: • Fitness: • Frontiersmen, Cowboys and Indians: • Fundamentals: • IT3 Tech: • Internet Tech: • Google: • Calendar: • News: • Good News: • Retrospect: • Science: • Science and Technology: • Natural Sciences: • Biology: • Molecular Biology: • Genomics: • Young at Heart: • (0) Comments: • (0) Trackbacks: • Permalink:

[ Tuesday, September 18, 2007 05:53 ]

Legacy Journal: Medical Grand Rounds: Federally Mandated Individual Health Insurance

Section:
Health and Medicine

Summary:
Presidential candidate leader, Senator (D-NY) Hillary Clinton, has partially opened her campaign playbook and announced the outline of her communitarian view of our future by restructuring one eighth of the American economy—health, medical care and insurance coverage.

A simple, common and wrong view was recently expressed by reporter and analyst Susan Denzer of the Kaiser Foundation and PBS Lehrer News Hour. Her basic analogy was that state mandated auto insurance for individuals was the model. So, why not mandated medical insurance so as to capture the more than 40 million ? U.S. citizens? who are “free riders” appearing daily to clog expensive emergency rooms? That is the current conventional view of the “Best and Brightest “ from Ivy encrusted think tank feasting on fat foundation funding.

Main:
But, think about the Hillary Plan for a moment.

* For many, including NYC yuppies, SF Seniors and Washington D.C. Senators, a car is optional and cheap subsidized public transport is available, reliable and used by hundreds of thousands daily. Riders include workers, visitors, shoppers and students. Many do not want or need a car. They opt out of the auto insurance market. There is no opting out of mandated Hillary Health.

* Speaking of students, most opt not to enroll in currently offered basic low cost school sponsored medical plans. Young, health single adults often choose to use discretionary funds to pay tuition, room and board, buy books, travel, and buy event tickets rather than pay for some Senior’s end of life hospital bill.

* Today, at Medicine Grand Rounds at the University of Rochester’s Strong Memorial Hsoptial the speaker was from the Mayo Medical School is topic was pharmacogenomics. His promise and vision was to use of “CHIP” technology to individualize standard therapies and dosing like anticoagulation with Warfarin. Globalization of demographic patterns, malpractice protection, and rapidly decreasing costs of the techology were his primary selling point. In the end, insurance pays for techology and the biotechology capitalists who are funding the west coast startups plan to recover their investments sooner rather than later.

* Biotechnology is not like the advertising Google model that was adopted by the nytimes Select service today. The Google model is give content, applications and services away free to the subscribers. The revenue is on the advertising side.

* Meanwhile, it is off the atrium of the Kornberg Building at the UofR for the displays by some medical high tech companies who are showing their wares to patients, students and staff.

* In addition,the Pittsford Senior Center is doing its best to motivate its members to exercise in addition to eat and socialize. Meanwhile falls and injuries at home continue to plague seniors. Exercise and conditioning continue to be the best of the low tech preventative strategies. It is good for candidates running for office as well as seniors who tend to become potted plants during the winter when their Florida phase is no longer possible.

* We note today the good news that the Fed has lowered the Discount Rate by 1/2%.

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Footnotes:

Posted by: webscribe2 on 09/18 at 05:53 AM
Calendar: • Demographics: • IT3 Tech: • Internet Tech: • Google: • Media Watch: • Medicine: • MegaMoves: • News: • Political Watch: • Science and Technology: • Natural Sciences: • Biology: • Biotechnology Education: • Molecular Biology: • Genomics: • Think Again: • Wary Eye: • Washington Watch: • (0) Comments: • (0) Trackbacks: • Permalink:

[ Monday, October 02, 2006 15:41 ]

The Nobel Prize in Medicine 2006: On Fire at Stanford

Section:
Awards and Scholarships

Summary:
Andrew Fire, PhD of the Stanford University School of Medicine is the corecipitent of a 2006 Nobel Prize. His work is in the area of gene regulation, control and expression. iRNA or double stranded RNA interference or “silencing” by viruses, or other carriers, into plant and animal cells is now a frequent wet lab technique with Strong clinical possibilities.

Significantly, Fire is 47 years old and his work was published just eight years ago. His relative youth is testimony to the fact that the road from birth, to education to experience to funded basic science investigation to applied science is now on a relative fast track.

Main:
Also on a fast track is the information, communication and media folks at Stanford. Today, they assembled a news conference that included the University President, the medical school Dean and Fire. The result is streamed from a website featuring a 27 minute, streamed video and smart media text, links and appropriate graphics.

The video is an extended opportunity for a humble scientist to acknowledge institutions, mentors, collegues, associates, staff and family for their contribution to his journey. Fire was particulary generous in his praise of the Carnegie Embryology Group in Baltimore, Maryland.

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Footnotes:

Posted by: eegotoguy on 10/02 at 03:41 PM
Calendar: • Monday: • IT3 Tech: • Internet Tech: • News: • Regional: • Science and Technology: • Natural Sciences: • Biology: • Molecular Biology: • Genomics: • (0) Comments: • (0) Trackbacks: • Permalink:

[ Friday, April 28, 2006 16:29 ]

Passions for Science in Davis

Section:
Science and Technology

Summary:
Friday tends to be Science and Technology Day in Davis and on the West Campus. West Campus is the Tupper Building and the Library of the UCD School of Medicine, the School of Veteranary Medicine and the Genomics and Medical Science Facility.

Main:
Today the focus was on translational lab research, clinical research and medical disease prevention, diagnosis and treatment:

* The first lecture was by the PI at the newly opened Institute for Stem Cell Reseach at the UCDMC in Sacramento. The subject was the use of stem cell tissue cultures and the harvesting of primative myocytes for using in experimental animal models. The emphasis was on those myocytes with characteristics that marked them as probable artial pacers.

* The second by the Director of the UCSF Dysplasia Clinic on the immunology and histopathology of HPV infection of the cervix. The cervical stroma of patients with HPV associated CIN have significant numbers of lymphoid germinal centers and dendritic cells, as well as macrophages. Factors that may contribute to an altered immunological status and recognition of self response is postulated.

* The third was by an exercise physiologist exployed by Merck as a clinical research coordinator and manager who spoke to group of post graduated students in excercise biology about his career path, life style choices and the basis skill set requirements of his job.

Together, the presentations shared common themes. Committment to science as professession. personal passion. and good communication skills.

More:

Footnotes:

Posted by: eegotoguy on 04/28 at 04:29 PM
Calendar: • News: • Science and Technology: • Natural Sciences: • Biology: • Molecular Biology: • Genomics: • UCDavis: • Athletics: • Exercise Physiology: • (0) Comments: • (0) Trackbacks: • Permalink:

[ Thursday, April 13, 2006 14:11 ]

Fusion Future: Beta Technology for Heartlanders

Section:
WebWise Review

Summary:
Davis is the site of a popular food chain called Fusions. It is all about multicultural cuisine. Not a bad idea given the diversity of the student body. This week’s news theme is all about fusing, some say confusing, computer operating systems and unravling the mysteries of DNA. Today, the nytimes Technology Section leads with yet another David Pogue article on the hot topic of running multiple VMs on the new Apple Intel Duo Core Macs. The fusion software is Parallel’s WorkStation 2.1,Beta3. Pogue notes that fusion IT is being remorphed weekly

Hot fusion topic two is a nytimes Tech article on using diagnostic DNA testing for detecting Oncogenes that are associated with some forms of cancer.

Hot fusion topic three is day’s announcement of another Beta from Google. Calendar is now integrated into Gmail and uses AJAX, so page content is dynamically updated without the delay of page refreshing or the unpredictablity of browser or network caching.

Main:
Each of these fusion technologies share some common features:

* They are from for profit American based companies.

* Each is early in the product development, testing and marketing cycle. They use future users to test and debug the software and documentation.

* All of them integrate and legerage existing technologies: multiple OS using VM; DNA SNP chips; Gmail and Event Calendaring.

* Internet Network Marketing, product developement, testing and distribution are at work.

* Each is on a rapid update/edit/download cycle.

Meanwhile, in Davis the Sun is out, the ground is moist and warming, Warren’s Chinese chop suey tree is in its glory and some students a pushing nuclear power as the magic solution to “ the global energy shortage crisis in Asia “. In the words of one young advocate, “Nuclear power can economically solve the global shortage of potable water and prevent the pending Global Warming Crisis”

Really? Valley Heartlands wonder what is wrong with free water from the sky in the form of rain. The fact that the free water cycle that has been wetting the Valley and snow packing the Sierra began its cyclic journey in the vast Pacific Ocean and includes no small amount of Sun powered evaporation from the surface of that great store house.

More:

Footnotes:

Posted by: eegotoguy on 04/13 at 02:11 PM
Calendar: • IT3 Tech: • Internet Tech: • Google: • News: • Hot Spot: • OSX: • Science and Technology: • Natural Sciences: • Biology: • Molecular Biology: • Genomics: • (0) Comments: • (0) Trackbacks: • Permalink:

[ Wednesday, April 12, 2006 16:47 ]

DNA Dustup in Davis

Section:
Public Events

Summary:
Yesterday, Troy Duster, an academic sociologist with a Northwestern University PhD pedigree, NYU credentials and a UCB title presented his perspective on the media and his participation with nytimes reporter, Amy Harmon on her most popular article an ancestry seeking via so called “recreational genomics”.

Main:
The professor led off with trivia and pop culture. His target was vitamins and mineral supplements that are targeting latinos, Asians and BTW, everyone else who buys their products and swallows their untested claims. Second he took on the marketing practices of big Pharma. These are easy targets. Third, he “revealed” that most, if not all Genetic Testing is by for profit companies. Surprise! Really?

To what is important about ideas concerning race?

Race appears to matter. Where, when and how one might ask.

* jobs, scholarships, services, funding, reparations, public policy formulation, data collection, diversity claims,

* At UCB, students are increasingly checking the mixed, unknown or rufuse to state box on the endless forms and questionaires they fillout.
Some are writing in their reaction; NOYDB. N stand for None. B stand for Business.

So, is your Gene Profile about to replace you astrologic sign at a bar conversation opener?

More:

Footnotes:

Posted by: eegotoguy on 04/12 at 04:47 PM
Calendar: • News: • Hot Seat: • Political Watch: • Science and Technology: • Natural Sciences: • Biology: • Molecular Biology: • Genomics: • Social Sciences: • (0) Comments: • (0) Trackbacks: • Permalink:

[ Tuesday, March 14, 2006 14:37 ]

News and Views on science from the Heartland

Section:
Commentary

Summary:
How often we heard the claim: “ All of the experts (scientists, doctors) agree that__ _ __. “ The appeal to authority argument is a sledgehammer that quiets the conversation and tends to empty the room quickly. Recently, at a continuing Legal Education Meeting on Environmental Law on the UCD campus partly sponsored by the King School of Law, that argument was made by one of the panel of experts. He opined that no paper had be published in Science or Nature in the past ten years that contradicted the theory that the long term trend in the warming of all the world’s spheres was human activity. Unanimity of opinion on theory among attorney may be common; it is rare among those on the science side of the house.

Main:
The very best of the science presentations on this campus and elsewhere involve intense questioning of statistical methods, bench technique, validation of data, peer review, the presence of bias, sources of funding, the status of collaborators, site reviews, alternative interpretations, and the transferability of a laboratory mouse model or computer simulation to the natural world where the rest of use live.

The more experienced the investigator, the more measured the voice. Reason prevails over Rhetoric and Dogma. Application follows the process of describing the precess. For example, the investigator may demonstrate the complex role of a novel protein in the activation of platlet associated coronary artery plaque rupture, clot fomation and myocardial infarction. The discovery of a novel protein may lead to a “knockout mice model” for testing the phenotypic expression in the deleted mutant in murines. The tale is now one of years of publishing, funding, recruiting and testing.

And then there is the novel theory of Dr. Haig, a Harvard evolutionary biologist published in today’s Science section of the nytimes. He apparently considers human preclampsia and the associated pathophysiology as part of a process called genomic imprinting that leads to a contest that is a Sum Zero Game characterized by conflict between the fetus and its maternal host for limited resources. Really? The result being a kind of genetic warfare between mother and fetus? Really? What the good doctor understands about the uniqueness of preeclampsia to the human species, the role of the placenta and the many maternal adapations is uncertain.

The point is this. What we believe, what know and what we understand about nature and complex systems like blood, the modelling of the tricusid aortic valve , pregnancy and climate are frequently dwarfed by what we do not yet understand and can not full explain.

More:

Footnotes:

Posted by: eegotoguy on 03/14 at 02:37 PM
Science and Technology: • Natural Sciences: • Biology: • Molecular Biology: • Genomics: • (0) Comments: • (0) Trackbacks: • Permalink:

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